Researchers have identified critical BIOS/UEFI vulnerabilities in the Illumina iSeq 100 DNA gene sequencer. The device uses an outdated BIOS implementation with CSM mode enabled, lacking Secure Boot and standard firmware write protections. This allows attackers with system access to overwrite the firmware, potentially bricking the device or installing a persistent firmware implant. The vulnerabilities highlight significant supply chain security risks due to the re-use of commodity hardware and outdated firmware. This issue also underscores the need for stringent configuration management and integrity checking for devices handling genomic data. This shows that even devices in a non-traditional tech sector are vulnerable to attack.