bioETH-Beacon: Confidential FHE Genomic Querying
Arxiv
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2026-06-01T00:00:00
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Abstract
As Beacon networks grow, two privacy risks remain: host institutions can see plaintext queries, and repeated rare-variant queries can support membership-inference attacks. We present bioETH-Beacon, a smart-contract prototype that runs the Beacon aggregate count query over encrypted data on a fully homomorphic Ethereum Virtual Machine (fhEVM). Hospitals upload encrypted marker-count entries, authorized researchers submit encrypted marker queries, and the contract returns an encrypted answer that is released, via the off-chain key-management service, only to the requester named in the contracts on-chain ACL.
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